2 mg / 5 mL SYRUP
BRONCHODILATOR

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FORMULATION:
Each 5 mL (1teaspoonful) contains:
Salbutamol (as sulfate)…………….......................….....................………2 mg

PRODUCT DESCRIPTION:
Salbutamol 2 mg / 5 mL (Primesal) Syrup used to treat breathing problems in people with asthma and similar conditions. Salbutamol (Primesal) Syrup is a cherry red colored syrup with strawberry flavor.

PHARMACODYNAMICS:
Salbutamol (Primesal) is a sympathomimetic agent with a relatively selective action on beta 2 adrenoceptor agonist. The action of salbutamol is to stimulate adenylyl cyclase which catalyzes the formation of cAMP. The
cAMP formed and mediates smooth muscle relaxation and bronchodilation.

PHARMACOKINETICS:
Salbutamol is readily absorbed from the gastro-intestinal tract and is subject to first pass metabolism in the liver. Peak plasma concentrations occur within one to four hours after oral administration. After multiple oral doses of
salbutamol 4 mg four times a day, steady-state plasma concentrations are obtained after 3 days. About half is excreted in the urine as an inactive sulfate conjugate following oral administration. The bioavailability of orally
administered salbutamol is about 50%.

INDICATIONS:
For chronic management or prophylactic therapy of bronchial asthma.

DOSAGE AND ADMINISTRATION:
Adult:
       10 mL (2 teaspoonfuls) taken 3 to 4 times daily.
Children:
       2 to 6 yrs. old
       2.5 – 5 mL (1/2 - 1 teaspoonful) taken 3 to 4 times daily.
       6 to 12 yrs. old
       5 mL (1 teaspoonful) taken 3 to 4 times daily.
Over 12 years of age
       5-10 mL (1-2 teaspoonfuls) taken 3 to 4 times daily or as prescribed by         the physician.

CONTRAINDICATIONS:
Patients with marked liver parenchymal damage also in patients with severe renal insufficiency when repeated
determinations of the plasma concentrations cannot be made.