100 mg Film-Coated Tablet

BETA ADRENOCEPTOR BLOCKER

 

FORMULATION:
Each film-coated tablet contains:
Metoprolol Tartrate, USP……….....……….............………...............….100 mg

PRODUCT DESCRIPTION:
Metoprolol Tartrate (Metoprim) 100 mg Film-Coated Tablet:
White to off-white film coated tablet, round, biconvex, bisected on one side, plain on the other side.

PHARMACODYNAMICS:
Metoprolol (Metoprim), like all other beta blockers, are competitive antagonists at beta-adrenergic sites and are used in the management of cardiovascular disorders such as hypertension, angina pectoris, cardiac arrhythmias and myocardial infarction. They are also given to control symptoms of sympathetic activity in alcohol withdrawal, anxiety states, hyperthyroidism and tremors. Metoprolol (Metoprim) is used for prophylaxis of migraine and of bleeding associated with portal hypertension.

PHARMACOKINETICS:
Metoprolol is readily and completely absorbed from the gastrointestinal tract but is subject to considerable first pass metabolism. Peak plasma concentrations vary widely and occur about 1.5 to 2 hours after a single oral dose. It is moderately lipid soluble. Metoprolol is widely distributed; it crosses the
blood brain barrier, the placenta, and is distributed into breast milk. It is slightly bound to plasma protein. It is extensively metabolized in the liver by oxidative deamination, O-dealkylation followed by oxidation, and aliphatic hydroxylation. The metabolites are excreted in the urine together with only small amounts
of unchanged Metoprolol. The rate of hydroxylation to a-hydroxymetoprolol is determined by genetic polymorphism; the half-life of Metoprolol in fast hydroxylation is stated 3 to 4 hours, where as in poor hydroxylation is 7 hours.

INDICATIONS:
Metoprolol (Metoprim) is used in the management of hypertension, angina pectoris, cardiac arrhythmias,
myocardial infarction and heart failure.